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Akter, Sharmin, Al Sad, Abdullah, Islam, Md. Khademul, Effath Rahman Mim, Saima. (1403). Gene Frequency of ABO Blood Group and Rh Factor Allele among the People of Sylhet, Bangladesh.. نشریه علمی دانشگاه سیستان و بلوچستان, 5(2), 8-15. doi: 10.22111/jep.2024.48158.1071
Sharmin Akter; Abdullah Al Sad; Md. Khademul Islam; Saima Effath Rahman Mim. "Gene Frequency of ABO Blood Group and Rh Factor Allele among the People of Sylhet, Bangladesh.". نشریه علمی دانشگاه سیستان و بلوچستان, 5, 2, 1403, 8-15. doi: 10.22111/jep.2024.48158.1071
Akter, Sharmin, Al Sad, Abdullah, Islam, Md. Khademul, Effath Rahman Mim, Saima. (1403). 'Gene Frequency of ABO Blood Group and Rh Factor Allele among the People of Sylhet, Bangladesh.', نشریه علمی دانشگاه سیستان و بلوچستان, 5(2), pp. 8-15. doi: 10.22111/jep.2024.48158.1071
Akter, Sharmin, Al Sad, Abdullah, Islam, Md. Khademul, Effath Rahman Mim, Saima. Gene Frequency of ABO Blood Group and Rh Factor Allele among the People of Sylhet, Bangladesh.. نشریه علمی دانشگاه سیستان و بلوچستان, 1403; 5(2): 8-15. doi: 10.22111/jep.2024.48158.1071

Gene Frequency of ABO Blood Group and Rh Factor Allele among the People of Sylhet, Bangladesh.

Journal of Epigenetics
دوره 5، شماره 2، بهمن 2024، صفحه 8-15    اصل مقاله (576.87 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22111/jep.2024.48158.1071
نویسندگان
Sharmin Akter* 1؛ Abdullah Al Sad2؛ Md. Khademul Islam3؛ Saima Effath Rahman Mim4
1Department of Epidemiology and Public Health, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University
2Faculty of Veterinary, Animal and Biomedical Sciences , Sylhet Agricultural University, Sylhet -3100
3Department of Epidemiology and Public health, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University , Sylhet -3100
4Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet -3100
چکیده
Knowledge of blood grouping is very important, especially for safer blood transfusions. The blood group and Rh factor of an individual is determined by the presence or absence of different antigens and Rh factor on the surface of the RBC, respectively. It can be determined in many ways, and we used the slide-method. The primary focus of this study was to find out the gene, allele, and phenotypic frequencies of the ABO blood group and Rh factor among the population of Sylhet. A total of 908 samples were collected, of which 180 were female and 728 were male. Blood group O was the most frequent (36.9%), followed by B (30.0%), A (24.9%), and AB (8.3%) group. In both genders, blood group frequency follows the same order (O>B>A>AB) but with a different percentage. In the current study, Rh+ve was dominant (95.5%) over Rh-ve. Additionally, in the case of blood group and Rh factor combination, this study found an order of O+ve > B+ve > A+ve > AB+ve > B-ve > A-ve > O-ve > AB-ve. The Hardy-Weinberg law was used to find out the allele and gene frequency. The most frequent allele was r[O] (0.60439), while the least frequent was p[A]. In case of gene frequency, heterozygous genes (AO, BO, AB) showed a higher frequency than homozygous genes, and among homozygous, O gene showed the highest frequency compared to others (AA, BB). This is the first-ever study found in Sylhet region within the mass population to find out the gene and allele frequency along with blood group and Rh factor. Though the result of our study differs from most of the studies found in Bangladesh and South-East Asian region, these results can be useful to study population genetics and form a safer and more reliable organ, tissue, and blood donation database.
کلیدواژه‌ها
Phenotypic؛ Gene-frequency؛ Allele-frequency؛ Heterozygous؛ Homozygous
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