اخبار و اعلانات

دانشگاه سیستان و بلوچستان

آمار

تعداد نشریات25
تعداد شماره‌ها483
تعداد مقالات5,023
تعداد مشاهده مقاله7,322,116
تعداد دریافت فایل اصل مقاله4,931,925
Dianat, Tahereh, Naiem Aminifard, Mohammad, Arish, Mohammad, Hussein Sangtrash, Mohammad, Poyandeh, Robab. (1399). Correlation between Promoter Hypermethylation and Expression Profiles of P15INK4b and P16INK4a Genes on Development of Pterygium Disease. نشریه علمی دانشگاه سیستان و بلوچستان, 2(1), 27-31. doi: 10.22111/jep.2020.5940
Tahereh Dianat; Mohammad Naiem Aminifard; Mohammad Arish; Mohammad Hussein Sangtrash; Robab Poyandeh. "Correlation between Promoter Hypermethylation and Expression Profiles of P15INK4b and P16INK4a Genes on Development of Pterygium Disease". نشریه علمی دانشگاه سیستان و بلوچستان, 2, 1, 1399, 27-31. doi: 10.22111/jep.2020.5940
Dianat, Tahereh, Naiem Aminifard, Mohammad, Arish, Mohammad, Hussein Sangtrash, Mohammad, Poyandeh, Robab. (1399). 'Correlation between Promoter Hypermethylation and Expression Profiles of P15INK4b and P16INK4a Genes on Development of Pterygium Disease', نشریه علمی دانشگاه سیستان و بلوچستان, 2(1), pp. 27-31. doi: 10.22111/jep.2020.5940
Dianat, Tahereh, Naiem Aminifard, Mohammad, Arish, Mohammad, Hussein Sangtrash, Mohammad, Poyandeh, Robab. Correlation between Promoter Hypermethylation and Expression Profiles of P15INK4b and P16INK4a Genes on Development of Pterygium Disease. نشریه علمی دانشگاه سیستان و بلوچستان, 1399; 2(1): 27-31. doi: 10.22111/jep.2020.5940

Correlation between Promoter Hypermethylation and Expression Profiles of P15INK4b and P16INK4a Genes on Development of Pterygium Disease

Journal of Epigenetics
دوره 2، شماره 1، بهار 2020، صفحه 27-31  XML اصل مقاله (244.09 K)
شناسه دیجیتال (DOI): 10.22111/jep.2020.5940
نویسندگان
Tahereh Dianat* 1؛ Mohammad Naiem Aminifard2؛ Mohammad Arish2؛ Mohammad Hussein Sangtrash1؛ Robab Poyandeh1
1Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran
2Department of Ophthalmology, Al-Zahra Eye Hospital, Zahedan University of Medical Sciences, Zahedan, Iran
چکیده
< p>Background: It is not thoroughly clear that what is the exact etiology of pterygium. Recently, it has been illustrated that pterygium is a benign and destructive condition. The aim of this study was to examine the correlation between promoter hypermethylation of P15INK4band P16INK4a genes on progress of pterygium. Materials and methods: We extracted DNA from 81 primary pterygium and 75 normal conjunctiva tissues. Methylation specific polymerase chain reaction (MSP) technique was used to analyze of promoter hypermethylation of P15INK4b and P16INK4a genes. The expression levels ofthesegenes were also assessed in mRNA from 23 pterygium and 18 normal conjunctiva tissue samples using real-time quantitative reverse transcriptase PCR.  Results: The frequency of methylation for P15INK4b was 97.5% and 72% among cases and controls respectively. P16INK4 gene methylation at promoter was 69.1% and 33.3% for pterygium and normal conjunctiva tissue respectively. A statistically significant relationship was found for methylation of P15INK4b and P16INK4a genes between cases and controls (p
کلیدواژه‌ها
Pterygium؛ Hypermethylation؛ Expression؛ P15INK4b Gene؛ P16INK4a Gene
آمار
تعداد مشاهده مقاله: 13
تعداد دریافت فایل اصل مقاله: 6


Contact Us | Help & Support | Site Map

Journal Management System. Designed by sinaweb.