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Analysis of DRD1 gene expression pattern in patients with glaucoma | ||
| Journal of Epigenetics | ||
| دوره 3، شماره 2، آذر 2022، صفحه 15-20 اصل مقاله (297.38 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22111/jep.2022.40753.1035 | ||
| نویسندگان | ||
| Mojtaba Reyhani1؛ Mohammad Arish2؛ Alireza Maleki2؛ Shahram Banaie2؛ Dor Mohammad Kordi-Tamandani* 3 | ||
| 1Department of Biology, Sistan and Baluchistan University, Iran | ||
| 2Department of Ophthalmology, Al-Zahra Eye Hospital, Zahedan University of Medical Sciences, Zahedan, Iran | ||
| 3Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran | ||
| چکیده | ||
| Background: Glaucoma is a term used to describe a group of diseases that progressively weaken the optic nerve and cause vision loss and eventually blindness. Glaucoma is one of the most common and controversial eye diseases. Dopamine, a neurotransmitter in the eye, regulates ciliary blood flow and aqueous humour production, which affects intraocular pressure and glaucoma. Based on previous studies on dopamine receptor ligands, it was concluded that the effect of dopamine on fluid production is stimulated by dopamine receptor 1 (D1) activation. Expression and translation of the DRD1 gene cause the production of the D1 receptor. Based on this, it was hypothesized that changes in DRD1 gene expression may play a role in the development of glaucoma. The aim of this study was to analyze DRD1 gene expression in patients with glaucoma. Materials and Methods: In this study, a statistical population of 40 people including 20 patients and 20 healthy individuals was used to analyze the effect of DRD1 gene expression on patients with glaucoma. After RNA extraction and cDNA synthesis, the Real-time quantitative PCR (qRT-PCR) technique was used and its data were analyzed by SPSS software and Mann-Whitney statistical method. Results: The results of this study indicate a significant difference (P = 0.015) in the expression of the DRD1 gene in patients with glaucoma compared to the control group. | ||
| کلیدواژه‌ها | ||
| Glaucoma؛ dopamine receptor D1A؛ Gene Expression؛ Receptors؛ Dopamine؛ Real-Time Polymerase Chain Reaction | ||
| مراجع | ||
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Kwon, S., Kim, S. H., Khang, D., & Lee, J. Y. (2020). Potential therapeutic usage of nanomedicine for glaucoma treatment. Int. J. Nanomed, 15, 5745. Arora, K. S., Jefferys, J. L., Maul, E. A., & Quigley, H. A. (2012). Choroidal thickness change after water drinking is greater in angle closure than in open-angle eyes. IOVS, 53(10), 6393-6402. Juneja, M., Thakur, S., Wani, A., Uniyal, A., Thakur, N., & Jindal, P. (2020). DC-Gnet for detection of glaucoma in retinal fundus imaging. Mach Vis Appl, 31, 1-14. Souzeau, E., Tram, K. H., Witney, M., Ruddle, J. B., Graham, S. L., Healey, P. R., & Craig, J. E. (2017). Myocilin predictive genetic testing for primary open-angle glaucoma leads to the early identification of at-risk individuals. OPHTDG, 124(3), 303-309. Wentz, S. M., Kim, N. J., Wang, J., Amireskandari, A., Siesky, B., & Harris, A. (2014). Novel therapies for open-angle glaucoma. F1000 Med. Rep, 6. Rizzo, M. I., Greco, A., De Virgilio, A., Gallo, A., Taverniti, L., Fusconi, M. & De Vincentiis, M. (2017). Glaucoma: recent advances in the involvement of autoimmunity. Immunol. Res., 65(1), 207-217. Wiggs, J. L., & Pasquale, L. R. (2017). Genetics of glaucoma. Human molecular genetics, 26(R1), R21-R27. Doucette, L. P., Rasnitsyn, A., Seifi, M., & Walter, M. A. (2015). The interactions of genes, age, and environment in glaucoma pathogenesis. Surv. Ophthalmol., 60(4), 310-326. Kim, J. H., & Caprioli, J. (2018). Intraocular pressure fluctuation: is it important? JOVR, 13(2), 170. Wostyn, P. (2019). Glaucoma is a dangerous interplay between ocular fluid and cerebrospinal fluid. Med. Hypotheses, 127, 97-99. McMonnies, C. W. (2017). Glaucoma history and risk factors. J. Optom., 10(2), 71-78. Wiggs, J. L., Yaspan, B. L., Hauser, M. A., Kang, J. H., Allingham, R. R., Olson, L. M., ... & Haines, J. L. (2012). Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet., 8(4), e1002654. Wang, C. X., Ge, X. Y., Wang, M. Y., Ma, T., Zhang, Y., & Lin, Y. (2020). Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells. Stem Cell Res. Ther., 11(1), 1-13. Ayano, G. J. J. M. D. T. (2016). Dopamine: receptors, functions, synthesis, pathways, locations and mental disorders: a review of literatur. J Ment Disord Treat, 2(120), 2. Belkhiri, A., Zhu, S., & El-Rifai, W. (2016). DARPP-32: from neurotransmission to cancer. Oncotarget, 7(14), 17631. Cho, K., Cho, M. H., Seo, J. H., Peak, J., Kong, K. H., Yoon, S. Y., & Kim, D. H. (2015). Calpain‐mediated cleavage of DARPP‐32 in A lzheimer's deisease. Aging cell, 14(5), 878-886. Hirasawa, H., Contini, M., & Raviola, E. (2015). Extrasynaptic release of GABA and dopamine by retinal dopaminergic neurons. Philos. Trans. R. Soc. Lond., B, Biol. Sci. PHILOS T R SOC B, 370(1672), 20140186. Yin, N., Yang, Y. L., Cheng, S., Wang, H. N., Hu, X., Miao, Y., & Wang, Z. (2020). Dopamine D2 receptor-mediated modulation of rat retinal ganglion cell excitability. Neurosci. Bull., 36(3), 230-242. Bucolo, C., Leggio, G. M., Drago, F., & Salomone, S. (2019). Dopamine outside the brain: The eye, cardiovascular system, and endocrine pancreas. Pharmacol. Ther., 203, 107392. Bucolo, C., Platania, C., Drago, F., Bonfiglio, V., Reibaldi, M., Avitabile, T., & Uva, M. (2018). Novel therapeutics in glaucoma management. Curr. Neuropharmacol., 16(7), 978-992. Pescosolido, N., Parisi, F., Russo, P., Buomprisco, G., & Nebbioso, M. (2013). Role of dopaminergic receptors in glaucomatous disease modulation. Biomed Res. Int., 2013. Cavallotti, C., Pescosolido, N., Pescosolido, V., & Iannetti, G. (1999). Determination of dopamine D1 receptors in the human uveo scleral tissue by light microscope autoradiography. Int. Ophthalmol., 23(3), 171-179. Pescosolido, N., Parisi, F., Russo, P., Buomprisco, G., & Nebbioso, M. (2013). Role of dopaminergic receptors in glaucomatous disease modulation. Biomed Res. Int., 2013. Prünte, C., Nuttli, I., Markstein, R., & Kohler, C. (1997). Effects of dopamine D-1 and D-2 receptors on intraocular pressure in conscious rabbits. J. Neural Transm. Suppl., 104(2-3), 111-123. Ke, Y., Li, W., Tan, Z., & Yang, Z. (2017). Induction of dopamine D1 and D5 receptors in R28 cells by light exposures. Biochem. Biophys. Res. Commun., 486(3), 686-692. Stone, R. A., Laties, A. M., Hemmings Jr, H. C., Ouimet, C. C., & Greengard, P. A. U. L. (1986). DARPP-32 in the ciliary epithelium of the eye: a neurotransmitter-regulated phosphoprotein of brain localizes to secretory cells. J. Histochem. Cytochem., 34(11), 1465-1468. Karnezis, T. A., Murphy, M. B., Weber, R. R., Nelson, K. S., Tripathi, B. J., & Tripathi, R. C. (1988). Effects of selective dopamine-1 receptor activation on intraocular pressure in man. Exp. Eye Res., 47(5), 689-697. | ||
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