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Mollaali, Milad, Jamali, Sara, Augend, Arsalan, Saberi, Eshaghali. (1402). Investigation of the NF-κB, TRAF1, and TRAF2 Relative Gene Expressions in a Population of Iranian Patients with Oral Squamous Cell Carcinoma: A Case-Control Study. نشریه علمی دانشگاه سیستان و بلوچستان, 4(1), 7-1. doi: 10.22111/jep.2023.44075.1049
Milad Mollaali; Sara Jamali; Arsalan Augend; Eshaghali Saberi. "Investigation of the NF-κB, TRAF1, and TRAF2 Relative Gene Expressions in a Population of Iranian Patients with Oral Squamous Cell Carcinoma: A Case-Control Study". نشریه علمی دانشگاه سیستان و بلوچستان, 4, 1, 1402, 7-1. doi: 10.22111/jep.2023.44075.1049
Mollaali, Milad, Jamali, Sara, Augend, Arsalan, Saberi, Eshaghali. (1402). 'Investigation of the NF-κB, TRAF1, and TRAF2 Relative Gene Expressions in a Population of Iranian Patients with Oral Squamous Cell Carcinoma: A Case-Control Study', نشریه علمی دانشگاه سیستان و بلوچستان, 4(1), pp. 7-1. doi: 10.22111/jep.2023.44075.1049
Mollaali, Milad, Jamali, Sara, Augend, Arsalan, Saberi, Eshaghali. Investigation of the NF-κB, TRAF1, and TRAF2 Relative Gene Expressions in a Population of Iranian Patients with Oral Squamous Cell Carcinoma: A Case-Control Study. نشریه علمی دانشگاه سیستان و بلوچستان, 1402; 4(1): 7-1. doi: 10.22111/jep.2023.44075.1049

Investigation of the NF-κB, TRAF1, and TRAF2 Relative Gene Expressions in a Population of Iranian Patients with Oral Squamous Cell Carcinoma: A Case-Control Study

Journal of Epigenetics
دوره 4، شماره 1، آذر 2023، صفحه 7-1    اصل مقاله (601.41 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22111/jep.2023.44075.1049
نویسندگان
Milad Mollaali1؛ Sara Jamali* 2؛ Arsalan Augend3؛ Eshaghali Saberi4
1Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
2Deptartment of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
3Department of Maxillofacial Surgery, Dental school, Zahedan University of Medical School, Zahedan, Iran
4Department of Endodontics, Faculty of Dentistry, Oral and Dental Diseases Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
چکیده
Objective: Oral squamous cell carcinoma (OSCC) is a frequently prevalent subtype of oral cancer with late detection and diagnosis and an elevated mortality rate. It can be triggered via genetic and environmental factors, creating several patient difficulties. The main concern is to comprehend the interaction between variables to explain the regulation of oral cancer, as well as the process of its occurrence. Nuclear factor kappa B (NF-κB) belongs to a class of induced transcription factors, controlling various genes responsible for several aspects of inflammation and immunological processes. It is regulated through diverse genes, such as TNF receptor-associated factor 1 (TRAF1) and TNF receptor-associated factor 2 (TRAF2). The disruption of this pathway may contribute to various health problems.
Materials and Methods: Eighteen paraffin-embedded oral cancer tissues and 18 oral mucosae tissues were applied to evaluate gene expression profiles via quantitative real-time PCR (qRT-PCR) in a population in Southeast Iran.
Results: NF-κB (95% CI = -0.804 to -0.222, p-value = 0.001), TRAF1 (95% CI = -3.201 to -1.018, p-value < 0.0001), and TRAF2 (95% CI = -1.802 to -0.86, p-value = 0.019) gene expressions were revealed a strong correlation with OSCC.
Conclusion: Our findings revealed that the increased gene expression levels of NF-κB, TRAF1, and TRAF2 are closely linked to clinical manifestations in OSCC.
کلیدواژه‌ها
Squamous Cell Carcinoma of Head and Neck؛ Real-Time Polymerase Chain Reaction؛ NF-kappa B؛ TNF Receptor-Associated Factor 1؛ TNF Receptor-Associated Factor 2؛ Iran
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