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Jafari, Ziaeddin, Pouranfard, Abdolrasoul, Rahimi, Negin. (1402). Electrochemical characterization and study the effect of Isoprenaline and Phenobarbital in human plasma by nanosensor. نشریه علمی دانشگاه سیستان و بلوچستان, 2(2), 22-36. doi: 10.22111/cpd.2023.46054.1028
Ziaeddin Jafari; Abdolrasoul Pouranfard; Negin Rahimi. "Electrochemical characterization and study the effect of Isoprenaline and Phenobarbital in human plasma by nanosensor". نشریه علمی دانشگاه سیستان و بلوچستان, 2, 2, 1402, 22-36. doi: 10.22111/cpd.2023.46054.1028
Jafari, Ziaeddin, Pouranfard, Abdolrasoul, Rahimi, Negin. (1402). 'Electrochemical characterization and study the effect of Isoprenaline and Phenobarbital in human plasma by nanosensor', نشریه علمی دانشگاه سیستان و بلوچستان, 2(2), pp. 22-36. doi: 10.22111/cpd.2023.46054.1028
Jafari, Ziaeddin, Pouranfard, Abdolrasoul, Rahimi, Negin. Electrochemical characterization and study the effect of Isoprenaline and Phenobarbital in human plasma by nanosensor. نشریه علمی دانشگاه سیستان و بلوچستان, 1402; 2(2): 22-36. doi: 10.22111/cpd.2023.46054.1028

Electrochemical characterization and study the effect of Isoprenaline and Phenobarbital in human plasma by nanosensor

Chemical Process Design
دوره 2، شماره 2، اسفند 2023، صفحه 22-36    اصل مقاله (2.26 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22111/cpd.2023.46054.1028
نویسندگان
Ziaeddin Jafari1؛ Abdolrasoul Pouranfard* 1؛ Negin Rahimi2
1Department of Chemical Engineering, Yasouj University, Yasouj, Iran
2Tehran University of Medical Sciences, Tehran, Iran
چکیده
An extremely sensitive and selective electrochemical sensor based on anatase TiO2 nanosheet hierarchical spheres (TiO2NSHSs), Pt nanoparticles (PtNPs), carbon paste electrode (CPE) and 2,3-dihydro-2-(3,4-dihydroxyphenyl) quinazolin-4(1H)-one (DHP) for determination of isoprenaline (IP) in the presence of phenobarbital (PB) was developed. The excellent synergistic effect of TiO2NSHSs, PtNPs and DHP showed significantly enhanced electrocatalytic activity for IP and PB. In order to characterize the developed nanosensor, the scanning electron microscope (SEM), electrochemical impedance spectroscopy (EIS) and voltammetry were used. Electrochemical behavior of the DHP/PtNPs/TiO2NSHSs/CPE sensor studied using differential pulse voltammetry (DPV), cyclic voltammetry (CV) and EIS. Several effective parameters were investigated and optimized on the nanosensor response. The proposed sensor, under the optimized conditions, showed two linear dynamic ranges from 0.05- 20.0 µM and 20.0-900.0 µM with a low detection limit of 7.0 nmol.L −1 for IP determination. Finally, the modified sensor was employed to determine the analytes in human blood plasma with ±0.3% error. Validation of the proposed method was performed using high-performance liquid chromatography (HPLC).
کلیدواژه‌ها
TiO2 nanosheet hierarchical spheres؛ Electrocatalytic properties؛ Electrochemical impedance spectroscopy؛ Phenobarbital
آمار
تعداد مشاهده مقاله: 175
تعداد دریافت فایل اصل مقاله: 135


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