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Abdi, Hosseinali, Kordi Tamandani, Dor Mohamad, Lagzian, Milad, Bakhshipour, Alireza. (1403). Differential Abundance Analysis of Gut Microbiome between Healthy Controls and Colorectal Cancer Patients. نشریه علمی دانشگاه سیستان و بلوچستان, 5(1), -. doi: 10.22111/jep.2024.45436.1055
Hosseinali Abdi; Dor Mohamad Kordi Tamandani; Milad Lagzian; Alireza Bakhshipour. "Differential Abundance Analysis of Gut Microbiome between Healthy Controls and Colorectal Cancer Patients". نشریه علمی دانشگاه سیستان و بلوچستان, 5, 1, 1403, -. doi: 10.22111/jep.2024.45436.1055
Abdi, Hosseinali, Kordi Tamandani, Dor Mohamad, Lagzian, Milad, Bakhshipour, Alireza. (1403). 'Differential Abundance Analysis of Gut Microbiome between Healthy Controls and Colorectal Cancer Patients', نشریه علمی دانشگاه سیستان و بلوچستان, 5(1), pp. -. doi: 10.22111/jep.2024.45436.1055
Abdi, Hosseinali, Kordi Tamandani, Dor Mohamad, Lagzian, Milad, Bakhshipour, Alireza. Differential Abundance Analysis of Gut Microbiome between Healthy Controls and Colorectal Cancer Patients. نشریه علمی دانشگاه سیستان و بلوچستان, 1403; 5(1): -. doi: 10.22111/jep.2024.45436.1055

Differential Abundance Analysis of Gut Microbiome between Healthy Controls and Colorectal Cancer Patients

Journal of Epigenetics
دوره 5، شماره 1، تیر 2024    اصل مقاله (538.18 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22111/jep.2024.45436.1055
نویسندگان
Hosseinali Abdi* 1؛ Dor Mohamad Kordi Tamandani2؛ Milad Lagzian3؛ Alireza Bakhshipour4
1Ph.D. in Molecular Genenetics, Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
2Professor, Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
3Assistant Professor, Department of Biology, University of Sistan and Baluchestan, Zahedan,
4Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran
چکیده
Colorectal cancer (CRC) is a significant public health burden, accounting for approximately 10% of all new cancer cases worldwide, making it the world’s third most deadly cancer. The causes of CRC are complex and environmental factors play a stronger role than genetic factors. The gut microbiome has been linked to several bowel cancers, such as CRC. The present study aimed to estimate differential abundance analysis of CRC versus HC groups of the colorectal microbiome. Biopsy samples were taken from the normal mucosa of 13 healthy controls (HC) and the tumor of 17 patients with CRC during colonoscopy. The microbiome of tumor tissue and normal mucosa was evaluated by 16S rRNA gene amplicon sequencing. Differential abundance analysis of CRC versus HC groups showed that Enterobacteriaceae, Bacteroides fragilis, Prevotella, Fusobacterium, Leptotrichia, Akkermansia muciniphila, Streptococcus, and Parabacteroides have drastic fold changes (P ≤ 0.05). A heat map and dendrogram of the 20 ascending operational taxonomic units (OTUs) based on the FDR (False Discovery Rate) p-value were constructed to visualize the similarity between CRC and HC samples. The significant difference in the differential abundance of bacteria taxa in CRC versus HC groups indicates that these bacteria can be important pathogens in the development and progression of CRC.
کلیدواژه‌ها
Colorectal cancer؛ Microbiome؛ 16S rRNA؛ Fusobacterium؛ Differential abundance analysis
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