اخبار و اعلانات
آمار
| تعداد نشریات | 33 |
| تعداد شماره‌ها | 764 |
| تعداد مقالات | 7,395 |
| تعداد مشاهده مقاله | 12,239,875 |
| تعداد دریافت فایل اصل مقاله | 8,352,010 |
The Potential Role of hsa_circ_0004214 as a Biomarker for Breast Cancer Prognosis | ||
| Journal of Epigenetics | ||
| دوره 5، شماره 2، بهمن 2024، صفحه 16-23 اصل مقاله (696.76 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22111/jep.2024.48402.1072 | ||
| نویسندگان | ||
| Marzieh Beikzadeh؛ Mahdieh Salimi* | ||
| Department of Medical Genetics, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran | ||
| چکیده | ||
| Breast cancer is the most important cause of cancer-related death among women. Finding cancer management biomarkers may improve cancer management strategies, patient outcomes, and quality of life. Recently circular RNA (circRNA) expression has attracted huge attention in cancer management. CircRNAs have a covalently closed loop structure that makes them resistant to exonuclease degradation and make them more stable than their linear counterparts. This study investigates the potential of hsa_circ_0004214 as a circRNA derived from the angiomotin gene on chromosome 11, as a candidate possible prognostic biomarker. SYBR Green real-time reverse transcription–polymerase chain reaction (RT-PCR) was used to assess the expression level of hsa_circ_0004214 in 40 breast ductal carcinoma tumors and whole blood samples from breast cancer patients, compared to the match control samples. The association between the expression levels of this circRNA and the clinical characteristics of breast cancer patients was assessed. The findings indicate that hsa_circ_0004214 expression elevated in triple-negative cases and at higher stages of the disease (P< 0.05). The hsa_circ_0004214 may proposed as a potential biomarker for breast cancer prognosis, with its elevated expression in advanced breast cancer situations proposing its utility in clinical settings. Further research is warranted to establish its prognostic value and potential implications in breast cancer management. | ||
| کلیدواژه‌ها | ||
| Neoplasia؛ circRNA؛ Biomarker؛ Breast Cancer | ||
|
آمار تعداد مشاهده مقاله: 274 تعداد دریافت فایل اصل مقاله: 66 |
||