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Alterations in the expression of pituitary solute carrier (SLCs) families, ubiquitin-protease system, and ATP pump genes of high and low weight broilers using a microarray database analysis | ||
| Journal of Epigenetics | ||
| دوره 5، شماره 2، بهمن 2024، صفحه 29-40 اصل مقاله (831 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22111/jep.2024.49968.1074 | ||
| نویسندگان | ||
| Yadollah Badakhshan* 1؛ Zahrai Roudbari2؛ Manuchehr Yousefi3 | ||
| 1Assistant professor Department of Animal Science, Faculty of Agriculture, University of Jiroft, | ||
| 22- Associated professor Department of Animal Science, Faculty of Agriculture, University of Jiroft | ||
| 3Department of Animal Sciences, Faculty of Agriculture, Saravan University, Saravan, Iran | ||
| چکیده | ||
| Selecting for juvenile body weight over the long term from a shared original population resulted in the creation of two distinct chicken lines: the low-weight selected line (LWS) and the high-weight selected line (HWS). Transport proteins encoded by solute carrier families operate within the inner mitochondrial membrane, facilitating the transport of metabolites. Ubiquitination, a dynamic and reversible process, plays a crucial role, alongside ATP-related genes, in maintaining cellular energy balance. The aim of this research was to clarify the distinction in pathway and system gene expression between high and low-weight broiler lines using microarray data previously documented on the GEO website (GEO Accession GSE122519 ). During weeks 1, 3, 5, and 7 of age, investigations revealed a notable reduction in SLC7A2 gene expression among the genes associated with the SLC families in HWS broilers during the first week of age. In the third week of age, there is an upregulation of SLCO2A1, SLC25A6, and SLC39A13, while SLC41A1 and SLC35B4 are downregulated. By the fifth week, SLC16A6 is upregulated along with SLC25A6, and in the seventh week, SLC35B4 is downregulated while SLC39A11 is upregulated compared to the LWS line (P<0.01). In the first week of age, there was an upregulation observed in relation to UBAP2L in the LWS line. By the third week, USP16 and RCJMB04_2 showed upregulation, followed by USP18 and USP16 in the fifth week. Additionally, HERPUD1 exhibited upregulation in the seventh week. In comparison to the HWS line, NUB1 and RCJMB04_3 displayed downregulation (P<0.01). Genes associated with ATP pumps exhibited 18 significant changes in gene expression. Specifically, 8 ATP pump genes were found to be highly expressed during the 7th week of age, while 4 genes showed increased expression during the third week of age in the HWS line compared to the LWS line (P<0.01). | ||
| کلیدواژهها | ||
| microarray؛ broiler؛ pituitary؛ gene؛ expression | ||
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آمار تعداد مشاهده مقاله: 309 تعداد دریافت فایل اصل مقاله: 142 |
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