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Arvand, Majid, Alipour, Shiva, Pourhabib, Akram. (1402). Electrochemical approach for the in situ synthesis of a poly(sulfosalicylic acid)/nickel oxide nanoparticles/MCM-41 nanocomposite for guanine detection. نشریه علمی دانشگاه سیستان و بلوچستان, 11(2), 40-51. doi: 10.22111/cnmst.2025.51292.1258
Majid Arvand; Shiva Alipour; Akram Pourhabib. "Electrochemical approach for the in situ synthesis of a poly(sulfosalicylic acid)/nickel oxide nanoparticles/MCM-41 nanocomposite for guanine detection". نشریه علمی دانشگاه سیستان و بلوچستان, 11, 2, 1402, 40-51. doi: 10.22111/cnmst.2025.51292.1258
Arvand, Majid, Alipour, Shiva, Pourhabib, Akram. (1402). 'Electrochemical approach for the in situ synthesis of a poly(sulfosalicylic acid)/nickel oxide nanoparticles/MCM-41 nanocomposite for guanine detection', نشریه علمی دانشگاه سیستان و بلوچستان, 11(2), pp. 40-51. doi: 10.22111/cnmst.2025.51292.1258
Arvand, Majid, Alipour, Shiva, Pourhabib, Akram. Electrochemical approach for the in situ synthesis of a poly(sulfosalicylic acid)/nickel oxide nanoparticles/MCM-41 nanocomposite for guanine detection. نشریه علمی دانشگاه سیستان و بلوچستان, 1402; 11(2): 40-51. doi: 10.22111/cnmst.2025.51292.1258

Electrochemical approach for the in situ synthesis of a poly(sulfosalicylic acid)/nickel oxide nanoparticles/MCM-41 nanocomposite for guanine detection

Challenges in Nano and Micro Scale Science and Technology
دوره 11، شماره 2، بهمن 2023، صفحه 40-51    اصل مقاله (912.52 K)
نوع مقاله: Original Research Paper
شناسه دیجیتال (DOI): 10.22111/cnmst.2025.51292.1258
نویسندگان
Majid Arvand* ؛ Shiva Alipour؛ Akram Pourhabib
University of Guilan
چکیده
Guanine, a purine base in deoxyribonucleic acid (DNA), has a low redox potential, making it susceptible to oxidation and contributing to DNA damage and mutations. In the current study, a new polymer nanocomposite consisting of nickel oxide-Mobile crystalline material-41 (NiO-MCM-41) nanocomposites and poly(5-sulfosalicylic acid) (PSSA) was prepared by electropolymerization for modification of the graphite/glassy carbon electrode (Gr/GCE) surface and sensitive measurement of the guanine. The synthesized nanocomposite was identified and confirmed by FE-SEM, EDX and FT-IR techniques. The electrochemical behavior of guanine on the surface of the PSSA/NiO-MCM-41/Gr/GCE was analyzed in optimal conditions using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. The proposed modified electrode achieved a satisfactory dynamic range between the anodic peak current and the concentration of guanine, with a linear range of 0.001–36 µM, a sensitivity of 0.977 µA/µM, and the detection limit (LOD) was determined to be 0.5 nM (signal/noise = 3). This sensor was successfully used in the determination of guanine in the real sample of fish sperm’s DNA.
کلیدواژه‌ها
DNA sample؛ Electropolymerization؛ Guanine؛ NiO-MCM-41 nanocomposite؛ Poly(5-sulfosalicylic acid)
آمار
تعداد مشاهده مقاله: 101
تعداد دریافت فایل اصل مقاله: 84


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