پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 31 |
| تعداد شمارهها | 834 |
| تعداد مقالات | 8,015 |
| تعداد مشاهده مقاله | 14,854,652 |
| تعداد دریافت فایل اصل مقاله | 9,587,702 |
Anticancer Potential of Cecropin Antimicrobial Peptides: A Systematic Review | ||
| Journal of Epigenetics | ||
| مقاله 3، دوره 6، شماره 2، بهمن 2025، صفحه 39-52 اصل مقاله (715.66 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22111/jep.2025.52041.1084 | ||
| نویسندگان | ||
| Arman Izadian1؛ Hadi Hasani* 2؛ Roza Zareidoodeji3؛ Sara Eslami4؛ Zahra Alaghehmand5؛ Kosar Daneshipour6؛ Mojgan Mohammadnejad1؛ Yalda Ghazizadeh7؛ Reyhaneh Ramezani8؛ Marzieh Mehrabinia9؛ Ali Rezaei10؛ Mohammadreza Sadr11 | ||
| 1Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 2Department of Medical Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 3Student researcher, department of biological sciences, University of Maryland Baltimore County, Baltimore, MD, USA. | ||
| 4Department of life sciences and biotechnology, Shahid Beheshti University, Tehran, Iran. | ||
| 5Bachelor's student, Department of Microbiology, Faculty of advanced science and technology, Islamic Azad University, Tehran, Iran. | ||
| 6Department of Molecular Medicine and Medical Biotechnology (DMMBM), University of Naples Federico II, Naples, Italy. | ||
| 7Student research committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. | ||
| 8Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran. | ||
| 9Student research committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. | ||
| 10Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 11Department of Pediatrics, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. | ||
| چکیده | ||
| Background: This systematic review investigates the anticancer properties of antimicrobial peptides (AMPs) belonging to the Cecropin family, emphasizing their promise as innovative and effective agents for cancer therapy. Methods: This review was conducted in accordance with the PRISMA guidelines to evaluate the potential anticancer effects of AMPs. The Advanced strategy of search in PubMed was: (((Cecropin*)) AND (((Neoplasm*)) OR (cancer*) OR (Tumor*) OR (Carcinoma))); and in the Science Direct and Scopus was: (((Cecropin)) AND (((Neoplasm)) OR (cancer) OR (Tumor) OR (Carcinoma))). Results: The Cecropin family comprises linear α-helical AMPs, also called host defense peptides (HDPs), characterized by their wide-ranging antimicrobial efficacy. Numerous studies reveal encouraging results for Cecropin A and B; however, some investigations focusing on less optimized analogs or specific combinations have reported ineffective outcomes. Cecropins are recognized for their relatively low host toxicity, positioning them as potential candidates for cancer treatment. Typically, AMPs contain fewer than 100 amino acids and exhibit cationicity, hydrophobicity, and an amphipathic structure. Recent research indicates that these AMPs also demonstrate notable anticancer activities. By leveraging the molecular attributes and functionalities of AMPs, it is possible to identify or design selective anticancer peptides (ACPs) for clinical application as novel therapeutic agents against cancer. Conclusion: The findings underscore the capability of Cecropin family peptides as targeted cancer therapies, showcasing their strong anticancer efficacy alongside minimal host toxicity. | ||
| کلیدواژهها | ||
| Anticancer peptides (ACPs)؛ Host Defense Peptides (HDPs)؛ Cecropin؛ Antimicrobial Peptides (AMPs)؛ Cancer Therapy؛ Peptide-based Cancer Treatment | ||
| مراجع | ||
|
Barnett GC, West CML, Dunning AM, Elliott RM, Coles CE, Pharoah PDP, et al. Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Vol. 9, Nature Reviews. Cancer. England, 2009. p. 134–42.
Cerón JM, Contreras-Moreno J, Puertollano E, de Cienfuegos GÁ, Puertollano MA, de Pablo MA. The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells. Peptides. 2010 Aug;31(8):1494–503.
Chan SC, Yau WL, Wang W, Smith DK, Sheu FS, Chen HM. Microscopic observations of the different morphological changes caused by anti-bacterial peptides on Klebsiella pneumoniae and HL-60 leukemia cells. J Pept Sci an Off Publ Eur Pept Soc. 1998 Nov;4(7):413–25.
Chen HM, Wang W, Smith D, Chan SC. Effects of the anti-bacterial peptide cecropin B and its analogs, cecropins B-1 and B-2, on liposomes, bacteria, and cancer cells. Biochim Biophys Acta - Gen Subj [Internet]. 1997;1336(2):171–9. Available from: https://www.sciencedirect.com/science/article/pii/S030441659700024X
Desales-Salazar E, Khusro A, Cipriano-Salazar M, Barbabosa-Pliego A, Rivas-Cáceres RR. Scorpion venoms and associated toxins as anticancer agents: update on their application and mechanism of action. J Appl Toxicol. 2020 Oct;40(10):1310–24.
Do N, Weindl G, Grohmann L, Salwiczek M, Koksch B, Korting HC, et al. Cationic membrane-active peptides - anticancer and antifungal activity, as well as penetration into human skin. Exp Dermatol. 2014 May;23(5):326–31.
Ebrahimdoust M, Hayati HM, Moghaddam MM, Bahreini M. A Short Cationic Peptide Derived from Cecropin and Melittin Peptides Induce Apoptosis in Jurkat and Raji Leukemia Cell Lines. Protein Pept Lett. 2023;30(6):477–85.
Gong L, Qu L, Li Z, Li Q, Xu H, Shen P, et al. Gene therapy with biosynthetic nanoscale peptide Cecropin A driven by the survivin promoter for hepatocarcinoma cells. J Biomed Nanotechnol. 2014 Jul;10(7):1391–9.
Henao Arias DC, Toro LJ, Téllez Ramirez GA, Osorio-Méndez JF, Rodríguez-Carlos A, Valle J, et al. Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. Peptides. 2021 Nov;145:170626.
Huang SW, Chen YC, Lin YH, Yeh CT. Clinical Limitations of Tissue Annexin A2 Level as a Predictor of Postoperative Overall Survival in Patients with Hepatocellular Carcinoma. J Clin Med. 2021 Sep;10(18).
Jin X, Mei H, Li X, Ma Y, Zeng A hua, Wang Y, et al. Apoptosis-inducing activity of the antimicrobial peptide cecropin of Musca domestica in human hepatocellular carcinoma cell line BEL-7402 and the possible mechanism. Acta Biochim Biophys Sin (Shanghai). 2010 Apr;42(4):259–65.
Jin X bao, Mei H fang, Pu Q hong, Shen J, Lu X mei, Chu F jiang, et al. Effects of Musca domestica cecropin on the adhesion and migration of human hepatocellular carcinoma BEL-7402 cells. Biol Pharm Bull. 2013;36(6):938–43.
Jiang J, Pan Y, Li J, Xia L. Cecropin-Loaded Zeolitic Imidazolate Framework Nanoparticles with High Biocompatibility and Cervical Cancer Cell Toxicity. Molecules. 2022 Jul;27(14).
Kaufmann CP, Tremp R, Hersberger KE, Lampert ML. Inappropriate prescribing: a systematic overview of published assessment tools. Eur J Clin Pharmacol. 2014 Jan;70(1):1–11.
Lai D, Visser-Grieve S, Yang X. Tumour suppressor genes in chemotherapeutic drug response. Biosci Rep. 2012 Aug;32(4):361–74.
Li X, Shen B, Chen Q, Zhang X, Ye Y, Wang F, et al. Antitumor effects of cecropin B-LHRH’ on drug-resistant ovarian and endometrial cancer cells. BMC Cancer. 2016 Mar;16:251.
Park Y, Lee DG, Hahm KS. Antibiotic activity of Leu-Lys rich model peptides. Biotechnol Lett. 2003 Aug;25(16):1305–10.
Park Y, Lee DG, Jang SH, Woo ER, Jeong HG, Choi CH, et al. A Leu-Lys-rich antimicrobial peptide: activity and mechanism. Biochim Biophys Acta. 2003 Feb;1645(2):172–82.
Pandey P, Singh T, Kumar S. Cognitive Offloading: Systematic Review of a Decade. Int J Indian Psychol. 2023 May 30;11:1545–63.
Răileanu M, Bacalum M. Cancer Wars: Revenge of the AMPs (Antimicrobial Peptides), a New Strategy against Colorectal Cancer. Toxins (Basel). 2023 Jul;15(7).
Rapôso C. Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives. J Clin Transl Res. 2017 May;3(2):233–49.
Srairi-Abid N, Othman H, Aissaoui D, BenAissa R. Anti-tumoral effect of scorpion peptides: Emerging new cellular targets and signaling pathways. Cell Calcium. 2019 Jun;80:160–74.
Shin SY, Kang JH, Jang SY, Kim Y, Kim KL, Hahm KS. Effects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells. Biochim Biophys Acta. 2000 Feb;1463(2):209–18.
Srisailam S, Arunkumar AI, Wang W, Yu C, Chen HM. Conformational study of a custom antibacterial peptide cecropin B1: implications of the lytic activity. Biochim Biophys Acta. 2000 Jun;1479(1–2):275–85.
Srisailam S, Kumar TK, Arunkumar AI, Leung KW, Yu C, Chen HM. Crumpled structure of the custom hydrophobic lytic peptide cecropin B3. Eur J Biochem. 2001 Aug;268(15):4278–84.
Soler M, González-Bártulos M, Soriano-Castell D, Ribas X, Costas M, Tebar F, et al. Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties. Org Biomol Chem. 2014 Jan 31;12.
Suttmann H, Retz M, Paulsen F, Harder J, Zwergel U, Kamradt J, et al. Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells. BMC Urol. 2008 Mar; 8:5.
Wu C, Geng X, Wan S, Hou H, Yu F, Jia B, et al. Cecropin-P17, an analog of Cecropin B, inhibits human hepatocellular carcinoma cell HepG-2 proliferation via regulation of ROS, Caspase, Bax, and Bcl-2. J Pept Sci an Off Publ Eur Pept Soc. 2015 Aug;21(8):661–8.
Wu J, Deng R, Yan J, Zhu B, Wang J, Xu Y, et al. A cell transmembrane peptide chimeric M (27-39)-HTPP targeted therapy for hepatocellular carcinoma. iScience. 2023 May;26(5):106766.
Wu YL, Xia LJ, Li JY, Zhang FC. CecropinXJ inhibits the proliferation of human gastric cancer BGC823 cells and induces cell death in vitro and in vivo. Int J Oncol. 2015 May;46(5):2181–93.
Xia L, Wu Y, Kang S, Ma J, Yang J, Zhang F. CecropinXJ, a silkworm antimicrobial peptide, induces cytoskeleton disruption in esophageal carcinoma cells. Acta Biochim Biophys Sin (Shanghai). 2014 Oct;46(10):867–76.
Xia L, Zhang F, Liu Z, Ma J, Yang J. Expression and characterization of cecropinXJ, a bioactive antimicrobial peptide from Bombyx mori (Bombycidae, Lepidoptera) in Escherichia coli. Exp Ther Med. 2013 Jun;5(6):1745–51.
Xia LJ, Wu YL, Zhang FC. Combination of cecropinXJ and LY294002 induces synergistic cytotoxicity, and apoptosis in human gastric cancer cells via inhibition of the PI3K/Akt signaling pathway. Oncol Lett. 2017 Dec;14(6):7522–8.
Xu P, Lv D, Wang X, Wang Y, Hou C, Gao K, et al. Inhibitory effects of Bombyx mori antimicrobial peptide cecropins on esophageal cancer cells. Eur J Pharmacol. 2020 Nov;887:173434.
Ye JS, Zheng XJ, Leung KW, Chen HM, Sheu FS. Induction of transient ion channel-like pores in a cancer cell by antibiotic peptide. J Biochem. 2004 Aug;136(2):255–9.
Yang E V, Sood AK, Chen M, Li Y, Eubank TD, Marsh CB, et al. Norepinephrine Up-regulates the Expression of Vascular Endothelial Growth Factor, Matrix Metalloproteinase (MMP)-2, and MMP-9 in Nasopharyngeal Carcinoma Tumor Cells. Cancer Res [Internet]. 2006 Nov 1;66(21):10357–64. Available from: https://doi.org/10.1158/0008-5472.CAN-06-2496
Zeng J, Wang J, Wu J, Deng R, Zhang L, Chen Q, et al. A novel antimicrobial peptide M1-8 targets the lysosomal pathway to inhibit autolysosome formation and promote apoptosis in liver cancer cells. J Cell Mol Med. 2023 Feb;27(3):340–52.
Zhu W, Hu L, Wang Y, Lv L, Wang H, Shi W, et al. A hemolysin secretion pathway-based novel secretory expression platform for efficient manufacturing of tag peptides and anti-microbial peptides in Escherichia coli. Bioresour Bioprocess. 2021 Nov;8(1):115. | ||
|
آمار تعداد مشاهده مقاله: 445 تعداد دریافت فایل اصل مقاله: 153 |
||